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Serum lactate and procalcitonin measurements in emergency room for the diagnosis and risk-stratification of patients with suspected infection.
- Source :
-
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2012 Nov; Vol. 17 (7), pp. 590-6. Date of Electronic Publication: 2012 Jul 21. - Publication Year :
- 2012
-
Abstract
- Objective: To study the contribution of lactate and procalcitonin (PCT) serum measurements for the diagnosis and the risk-stratification of patients with suspected infection presenting to the ED.<br />Methods: Single-center one year observational study on 462 consecutive patients. Multivariate analysis to assess variables associated with sepsis, severe sepsis, septic shock and severe outcome.<br />Results: Multivariate analysis (Odds ratio [95% CI]), showed that PCT was the best independent variable to identify sepsis (3.98 [2.60-6.10]), while lactate was the best to diagnose severe sepsis (10.88 [6.51-18.19]). Patients with both lactate above 2 mmol·L(-1) and PCT above 0.8 ng·mL(-1) had an enhanced risk of severe outcome.<br />Conclusions: the dosages of lactate and PCT are complementary for the diagnosis and risk-stratification of patients evaluated in the ED for suspected infection.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Area Under Curve
Biomarkers blood
Calcitonin Gene-Related Peptide
Cohort Studies
Emergency Service, Hospital
Female
Hospitalization
Humans
Intensive Care Units
Male
Middle Aged
Multivariate Analysis
ROC Curve
Risk Assessment
Systemic Inflammatory Response Syndrome blood
Systemic Inflammatory Response Syndrome mortality
Young Adult
Calcitonin blood
Lactic Acid blood
Protein Precursors blood
Systemic Inflammatory Response Syndrome diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1366-5804
- Volume :
- 17
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
- Publication Type :
- Academic Journal
- Accession number :
- 22817478
- Full Text :
- https://doi.org/10.3109/1354750X.2012.704645