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New adamantane derivatives can overcome resistance of influenza A(H1N1)pdm2009 and A(H3N2) viruses to remantadine.

Authors :
Shibnev VA
Garaev TM
Finogenova MP
Shevchenko ES
Burtseva EI
Source :
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Jun; Vol. 153 (2), pp. 233-5.
Publication Year :
2012

Abstract

New adamantane derivatives with amino acid residues and other bifunctional compounds were synthesized and their antiviral activity towards influenza A(H1N1)pdm and A(H3N2) viruses was studied. Some of these adamantane derivatives completely suppressed replication of remantadine-resistant influenza A virus strains.

Subjects

Subjects :
Adamantane pharmacology
Drug Resistance, Viral
Rimantadine pharmacology
Adamantane analogs & derivatives
Antiviral Agents pharmacology
Influenza A Virus, H1N1 Subtype drug effects
Influenza A Virus, H3N2 Subtype drug effects

Details

Language :
English; Russian
ISSN :
1573-8221
Volume :
153
Issue :
2
Database :
MEDLINE
Journal :
Bulletin of experimental biology and medicine
Publication Type :
Academic Journal
Accession number :
22816091
Full Text :
https://doi.org/10.1007/s10517-012-1684-x
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