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IgG autoantibody response against keratinocyte cadherins in endemic pemphigus foliaceus (fogo selvagem).
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 2012 Nov; Vol. 132 (11), pp. 2573-80. Date of Electronic Publication: 2012 Jul 19. - Publication Year :
- 2012
-
Abstract
- It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS). Isolated reports have shown that in certain patients with these diseases, autoantibodies against other desmosomal cadherins and E-cadherin may also be present. The goal of this investigation was to determine whether FS patients and normal individuals living in endemic areas possess autoantibodies against other desmosomal cadherins and E-cadherin. By testing a large number of FS and endemic control sera by ELISA, we found a consistent and specific autoantibody response against Dsg1 and other keratinocyte cadherins in these individuals, which is quite different from healthy individuals from the United States (US controls). Overall, the highest correlations among the autoantibody responses tested were in the endemic controls, followed by FS patients, and lowest in the US controls. These findings suggest that multiple, perhaps cross-reactive, keratinocyte cadherins are recognized by FS patients and endemic controls.
- Subjects :
- Adult
Brazil
Cadherins genetics
Cadherins immunology
Cross Reactions immunology
Desmoglein 1 genetics
Desmoglein 1 immunology
Desmoglein 2 genetics
Desmoglein 2 immunology
Desmoglein 3 genetics
Desmoglein 3 immunology
Desmogleins genetics
Desmogleins immunology
Desmosomal Cadherins genetics
Humans
ROC Curve
Recombinant Proteins genetics
Recombinant Proteins immunology
United States
Autoantibodies immunology
Desmosomal Cadherins immunology
Immunoglobulin G immunology
Keratinocytes immunology
Pemphigus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1747
- Volume :
- 132
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 22810308
- Full Text :
- https://doi.org/10.1038/jid.2012.232