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Giant cell ependymoma-report of three cases and review of the literature.
- Source :
-
International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2012; Vol. 5 (5), pp. 458-62. Date of Electronic Publication: 2012 May 05. - Publication Year :
- 2012
-
Abstract
- Ependymomas constitute the most common type of primary spinal cord tumors, and are subclassified as myxopapillary ependymoma, classic ependymoma, and anaplastic ependymoma. Ependymomas can be further subclassified based on morphologic phenotype: cellular, papillary, tanycytic, clear cell, pigmented and epithelioid. Giant cell ependymoma (GCE), a rare variant, has recently been described. Reported cases have exhibited a wide anatomic distribution, including spinal cord, cerebrum and cerebellum. We report here three cases of GCE, arising from cerebrum in a 5-year-old girl, spinal cord in a 34-year-old female and cerebellum in an 86-year-old female respectively. Histologically those cases showed prominent pleomorphic giant cells with focal perivascular pseudorosettes in all cases. Tumor cells were immunopositive for GFAP and EMA. Only the first case was qualified for anaplastic ependymoma. No recurrence was noted in these three cases after 57, 46 and 6 months of follow-up respectively. By reviewing the literature, GCEs arising from spinal cord and cerebellum tended to have low-grade morphology while supratentorially located GCEs tended to have anaplastic features. GCEs were preferentially located in extraventricular regions. Anaplastic GCEs in adult population seemed to pursue a more aggressive behavior. Gross total resection should still be the main treatment for GCEs.
- Subjects :
- Adult
Aged, 80 and over
Biomarkers, Tumor metabolism
Cerebellar Neoplasms metabolism
Cerebellar Neoplasms surgery
Cerebrum metabolism
Cerebrum pathology
Child, Preschool
Ependymoma metabolism
Ependymoma surgery
Female
Giant Cells metabolism
Humans
Spinal Cord Neoplasms metabolism
Spinal Cord Neoplasms pathology
Spinal Cord Neoplasms surgery
Treatment Outcome
Cerebellar Neoplasms pathology
Ependymoma pathology
Giant Cells pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1936-2625
- Volume :
- 5
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of clinical and experimental pathology
- Publication Type :
- Academic Journal
- Accession number :
- 22808300