Back to Search
Start Over
Drug discovery prospect from untapped species: indications from approved natural product drugs.
- Source :
-
PloS one [PLoS One] 2012; Vol. 7 (7), pp. e39782. Date of Electronic Publication: 2012 Jul 11. - Publication Year :
- 2012
-
Abstract
- Due to extensive bioprospecting efforts of the past and technology factors, there have been questions about drug discovery prospect from untapped species. We analyzed recent trends of approved drugs derived from previously untapped species, which show no sign of untapped drug-productive species being near extinction and suggest high probability of deriving new drugs from new species in existing drug-productive species families and clusters. Case histories of recently approved drugs reveal useful strategies for deriving new drugs from the scaffolds and pharmacophores of the natural product leads of these untapped species. New technologies such as cryptic gene-cluster exploration may generate novel natural products with highly anticipated potential impact on drug discovery.
- Subjects :
- Biological Products chemistry
Cyanobacteria genetics
Drug Approval
Drug Evaluation, Preclinical
Fungi genetics
Humans
Intellectual Property
Multigene Family
Plants genetics
Biological Products isolation & purification
Cyanobacteria chemistry
Drug Discovery statistics & numerical data
Fungi chemistry
Plants chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 7
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 22808057
- Full Text :
- https://doi.org/10.1371/journal.pone.0039782