Back to Search
Start Over
Lower antibody levels to Staphylococcus aureus exotoxins are associated with sepsis in hospitalized adults with invasive S. aureus infections.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2012 Sep 15; Vol. 206 (6), pp. 915-23. Date of Electronic Publication: 2012 Jul 17. - Publication Year :
- 2012
-
Abstract
- Background: Staphylococcus aureus has numerous virulence factors, including exotoxins that may increase the severity of infection. This study was aimed at assessing whether preexisting antibodies to S. aureus toxins are associated with a lower risk of sepsis in adults with S. aureus infection complicated by bacteremia.<br />Methods: We prospectively identified adults with S. aureus infection from 4 hospitals in Baltimore, MD, in 2009–2011. We obtained serum samples from prior to or at presentation of S. aureus bacteremia to measure total immunoglobulin G (IgG) and IgG antibody levels to 11 S. aureus exotoxins. Bacterial isolates were tested for the genes encoding S. aureus exotoxins using polymerase chain reaction (PCR).<br />Results: One hundred eligible subjects were included and 27 of them developed sepsis. When adjusted for total IgG levels and stratified for the presence of toxin in the infecting isolate as appropriate, the risk of sepsis was significantly lower in those patients with higher levels of IgG against α-hemolysin (Hla), δ-hemolysin (Hld), Panton Valentine leukocidin (PVL), staphylococcal enterotoxin C-1 (SEC-1), and phenol-soluble modulin α3 (PSM-α3).<br />Conclusions: Our results suggest that higher antibody levels against Hla, Hld, PVL, SEC-1, and PSM-α3 may protect against sepsis in patients with invasive S. aureus infections.
- Subjects :
- Adult
Aged
Bacterial Proteins immunology
Cohort Studies
Female
Hospitalization
Humans
Immunoglobulin G blood
Male
Middle Aged
Odds Ratio
Risk Factors
Sepsis immunology
Staphylococcal Infections microbiology
Staphylococcus aureus metabolism
Antibodies, Bacterial blood
Exotoxins immunology
Sepsis microbiology
Staphylococcal Infections immunology
Staphylococcus aureus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 206
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 22807524
- Full Text :
- https://doi.org/10.1093/infdis/jis462