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cAMP-dependent phosphorylation of microtubule-associated protein-2 during treatment of sodium valproate and audiogenic kindling.

Authors :
Savina TA
Shchipakina TG
Source :
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2011 Nov; Vol. 152 (1), pp. 53-7.
Publication Year :
2011

Abstract

Administration of anticonvulsant sodium valproate alleviated audiogenic seizures in Krushinskii-Molodkina rats, which was accompanied by a decrease in cAMP-dependent phosphorylation of microtubule-associated protein MAP2 in the hippocampus ex vivo. In contrast, audiogenic kindling resulted in a marked increase in MAP2 phosphorylation at cAMP-dependent protein kinase-specific sites. These changes in the state of MAP2 phosphorylation providing restructuring of dendrites in response to specific influences modulate neuronal activity and are the important mechanisms of neuronal plasticity.

Details

Language :
English; Russian
ISSN :
1573-8221
Volume :
152
Issue :
1
Database :
MEDLINE
Journal :
Bulletin of experimental biology and medicine
Publication Type :
Academic Journal
Accession number :
22803039
Full Text :
https://doi.org/10.1007/s10517-011-1452-3