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cAMP-dependent phosphorylation of microtubule-associated protein-2 during treatment of sodium valproate and audiogenic kindling.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2011 Nov; Vol. 152 (1), pp. 53-7. - Publication Year :
- 2011
-
Abstract
- Administration of anticonvulsant sodium valproate alleviated audiogenic seizures in Krushinskii-Molodkina rats, which was accompanied by a decrease in cAMP-dependent phosphorylation of microtubule-associated protein MAP2 in the hippocampus ex vivo. In contrast, audiogenic kindling resulted in a marked increase in MAP2 phosphorylation at cAMP-dependent protein kinase-specific sites. These changes in the state of MAP2 phosphorylation providing restructuring of dendrites in response to specific influences modulate neuronal activity and are the important mechanisms of neuronal plasticity.
- Subjects :
- Analysis of Variance
Anticonvulsants therapeutic use
Cyclic AMP-Dependent Protein Kinases metabolism
Enzyme Activation
Epilepsy, Reflex enzymology
Epilepsy, Reflex metabolism
Hippocampus drug effects
Hippocampus enzymology
Hippocampus metabolism
Phosphorylation
Valproic Acid therapeutic use
Anticonvulsants pharmacology
Cyclic AMP metabolism
Epilepsy, Reflex drug therapy
Microtubule-Associated Proteins metabolism
Protein Processing, Post-Translational
Valproic Acid pharmacology
Subjects
Details
- Language :
- English; Russian
- ISSN :
- 1573-8221
- Volume :
- 152
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22803039
- Full Text :
- https://doi.org/10.1007/s10517-011-1452-3