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Protection of mice against infection with wild-type Mengo virus and an interferon sensitive mutant (IS-1) by polynucleotides and interferons.
- Source :
-
The Journal of general virology [J Gen Virol] 1979 Jul; Vol. 44 (1), pp. 255-60. - Publication Year :
- 1979
-
Abstract
- Single-stranded polynucleotide preparations [tRNA, poly(rI) plus poly(ho5C)-copolymer] which protect mice against picornavirus infections without inducing interferon, protected mice equally against infection with an interferon-sensitive mutant (IS-1) of Mengo virus and with wild-type virus (IS+). Poly(rI) . poly(rC), and mouse macrophage interferon [i.e. serum from mice treated with poly(rI) . poly(rC)] protected mice equally against infections with the two viruses, but fibroblast interferon protected better against infection with the interferon-sensitive mutant than with the wild-type virus. These and other results indicate that: Mengo virus had a genetic locus affecting sensitivity to fibroblast but not macrophage interferon; these two types of interferon have different mechanisms of action against Mengo virus infections in mice; Mengo virus genes controlling sensitivity to fibroblast interferon may modulate disease since infection in vivo induces only fibroblast interferon; the antiviral activity of the single-stranded polynucleotides is unlikely to be mediated by induction of either macrophage or fibroblast interferon.
- Subjects :
- Animals
Escherichia coli
Fibroblasts
Macrophages
Mengovirus genetics
Mengovirus growth & development
Mice
Mutation
Species Specificity
Enterovirus Infections prevention & control
Interferons pharmacology
Mengovirus drug effects
RNA, Bacterial pharmacology
RNA, Transfer pharmacology
Virus Replication drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1317
- Volume :
- 44
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of general virology
- Publication Type :
- Academic Journal
- Accession number :
- 227997
- Full Text :
- https://doi.org/10.1099/0022-1317-44-1-255