New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.

Authors :: Carneiro PF
do Nascimento SB
Pinto AV
Pinto Mdo C
Lechuga GC
Santos DO
dos Santos Júnior HM
Resende JA
Bourguignon SC
Ferreira VF
Source :: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2012 Aug 15; Vol. 20 (16), pp. 4995-5000. Date of Electronic Publication: 2012 Jun 21.
Publication Year :: 2012
Abstract: New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)

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