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Oxidative damage, inflammation, and Toll-like receptor 4 pathway are increased in preeclamptic patients: a case-control study.
- Source :
-
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2012; Vol. 2012, pp. 636419. Date of Electronic Publication: 2012 Jun 24. - Publication Year :
- 2012
-
Abstract
- Problem: There was no direct correlation between plasma and placental oxidative damage parameters and inflammation and evidence of TLR4 pathway activation in the placenta in preeclamptic (PE) patients.<br />Method of Study: 33 PE patients and 33 normotensive pregnant women were included. The maternal section of the placenta and blood were collected to the determination of oxidative damage markers (thiobarbituric acid reactive species and protein carbonyls), inflammatory response (interleukin-6 and myeloperoxidase activity), and activation of the TLR-4-NF-kB pathway.<br />Results: An increase of IL-6 levels in both plasma and placenta was observed, but myeloperoxidase activity was not significantly different comparing the groups. Oxidative damage parameters were increased in plasma and placenta in PE patients. A significant increase of the protein levels of TLR-4 and NF-kB was observed in the placenta.<br />Conclusion: The TLR4-NF-kB pathway is upregulated in PE, probably generating local and systemic inflammatory response that is followed by local and systemic oxidative damage.
- Subjects :
- Adult
Biomarkers blood
Case-Control Studies
Female
Humans
Inflammation blood
Interleukin-6 blood
Myeloid Differentiation Factor 88 metabolism
NF-kappa B metabolism
Peroxidase metabolism
Placenta enzymology
Pre-Eclampsia blood
Pregnancy
Pregnancy Proteins metabolism
Protein Carbonylation
Thiobarbituric Acid Reactive Substances metabolism
Inflammation complications
Oxidative Stress
Pre-Eclampsia pathology
Signal Transduction
Toll-Like Receptor 4 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1942-0994
- Volume :
- 2012
- Database :
- MEDLINE
- Journal :
- Oxidative medicine and cellular longevity
- Publication Type :
- Academic Journal
- Accession number :
- 22792416
- Full Text :
- https://doi.org/10.1155/2012/636419