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Genomics of alternative sulfur utilization in ascomycetous yeasts.
- Source :
-
Microbiology (Reading, England) [Microbiology (Reading)] 2012 Oct; Vol. 158 (Pt 10), pp. 2585-2597. Date of Electronic Publication: 2012 Jul 12. - Publication Year :
- 2012
-
Abstract
- Thirteen ascomycetous yeast strains with sequenced genomes were assayed for their ability to grow on chemically defined medium with 16 different sulfur compounds as the only significant source of sulfur. These compounds included sulfoxides, sulfones, sulfonates, sulfamates and sulfate esters. Broad utilization of alternative sulfur sources was observed in Komagataella pastoris (syn. Pichia pastoris), Lodderomyces elongisporus, Millerozyma farinosa (syn. Pichia sorbitophila), Pachysolen tannophilus, Scheffersomyces stipitis (syn. Pichia stipitis), Spathaspora passalidarum, Yamadazyma tenuis (syn. Candida tenuis) and Yarrowia lipolytica. Kluyveromyces lactis, Saccharomyces cerevisiae and Zygosaccharomyces rouxii were mainly able to utilize sulfonates and sulfate esters, while Lachancea thermotolerans and Schizosaccharomyces pombe were limited to aromatic sulfate esters. Genome analysis identified several candidate genes with bacterial homologues that had been previously shown to be involved in the utilization of alternative sulfur sources. Analysis of candidate gene promoter sequences revealed a significant overrepresentation of DNA motifs that have been shown to regulate sulfur metabolism in Sacc. cerevisiae.
- Subjects :
- Ascomycota classification
Ascomycota genetics
Ascomycota growth & development
Culture Media
DNA, Fungal analysis
DNA, Fungal chemistry
DNA, Fungal genetics
Fungal Proteins genetics
Gene Expression Regulation, Fungal
Saccharomyces cerevisiae genetics
Saccharomyces cerevisiae growth & development
Saccharomyces cerevisiae metabolism
Saccharomycetales classification
Saccharomycetales genetics
Saccharomycetales growth & development
Saccharomycetales metabolism
Schizosaccharomyces genetics
Schizosaccharomyces growth & development
Schizosaccharomyces metabolism
Sulfur Compounds metabolism
Ascomycota metabolism
Fungal Proteins metabolism
Genomics
Sulfur metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1465-2080
- Volume :
- 158
- Issue :
- Pt 10
- Database :
- MEDLINE
- Journal :
- Microbiology (Reading, England)
- Publication Type :
- Academic Journal
- Accession number :
- 22790398
- Full Text :
- https://doi.org/10.1099/mic.0.060285-0