Back to Search
Start Over
Thymic lymphosarcoma with brain involvement in a Holstein heifer.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2012 Nov; Vol. 74 (11), pp. 1501-4. Date of Electronic Publication: 2012 Jun 18. - Publication Year :
- 2012
-
Abstract
- An 8-month-old Holstein heifer with cervical enlargement was suspected of thymic lymphosarcoma given clinical signs of depression, tendency to lie down, cervical mass, jugular vein distension, conjunctival hyperemia, and ruminal tympany. Unilateral Horner's syndrome was also observed. Increased serum total lactate dehydrogenase (LDH), LDH isozyme (LDH-2, and LDH-3) and serum thymidine kinase activity were observed. The findings of fine needle aspiration cytology of the cervical mass revealed large lymphoblasts with mitoses present. These findings strongly suggested the diagnosis of lymphosarcoma. Necropsy revealed a large mass in the cervical thymic region, which compressed the esophagus and trachea. Cranial masses in the frontal sinus and multiple extradural sites throughout the cranial vault were also recorded. Histopathological examination confirmed the diagnosis of thymic lymphosarcoma and demonstrated the brain involvement of neoplastic lymphoid cells in the cerebrum. This is a rare clinical case of thymic lymphosarcoma accompanied by brain metastasis in a Holstein heifer.
- Subjects :
- Animals
Biopsy, Fine-Needle veterinary
Cattle
Cattle Diseases virology
Fatal Outcome
Female
Horner Syndrome pathology
L-Lactate Dehydrogenase blood
Thymidine Kinase blood
Thymus Neoplasms pathology
Brain Neoplasms secondary
Cattle Diseases pathology
Enzootic Bovine Leukosis pathology
Horner Syndrome veterinary
Thymus Neoplasms veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1347-7439
- Volume :
- 74
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 22785125
- Full Text :
- https://doi.org/10.1292/jvms.12-0210