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Jiangxienone, a new compound with potent cytotoxicity against tumor cells from traditional Chinese medicinal mushroom Cordyceps jiangxiensis.
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2012 Jul; Vol. 9 (7), pp. 1349-55. - Publication Year :
- 2012
-
Abstract
- A new compound, named jiangxienone, has been isolated from a culture of the traditional Chinese medicinal mushroom Cordyceps jiangxiensis, and its chemical structure was established on the basis of spectroscopic and chemical techniques. Jiangxienone showed potent cytotoxic effects against human gastric adenocarcinoma SGC-7901 cell and human lung carcinoma A549 cell with IC(50) values ranging from 1.38 to 2.93 μM, i.e., with at least approximately six-fold stronger cytotoxicity than cisplatin, a first-line chemotherapy drug for cancer patients.<br /> (Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich.)
- Subjects :
- Cell Line, Tumor
Cell Survival
Dose-Response Relationship, Drug
Humans
Inhibitory Concentration 50
Agaricales chemistry
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cyclohexanones chemistry
Cyclohexanones pharmacology
Indans chemistry
Indans pharmacology
Medicine, Chinese Traditional
Subjects
Details
- Language :
- English
- ISSN :
- 1612-1880
- Volume :
- 9
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 22782880
- Full Text :
- https://doi.org/10.1002/cbdv.201100244