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Heparin rescues sepsis-associated acute lung injury and lethality through the suppression of inflammatory responses.
- Source :
-
Inflammation [Inflammation] 2012 Dec; Vol. 35 (6), pp. 1825-32. - Publication Year :
- 2012
-
Abstract
- Heparin, a potent blood anticoagulant, is known to possess anti-inflammatory activity. In this work, we investigated whether heparin can ameliorate acute lung injury and lethal response in lipopolysaccharide (LPS)-induced mouse model of sepsis. We found that heparin effectively rescued lethality, improved lung pathological changes, inhibited myeloperoxidase (MPO) activity, and reduced malondialdehyde (MDA) level, lung wet/dry weight ratio and Evans blue values in LPS-induced septic mice. In addition, heparin also inhibited the release of tumor necrosis factor (TNF)-α, interleukin-6 (IL-6) and IL-1β in serum and decreased the expression of p-p38, nuclear factor κB (NF-κB) and p-c-SRC kinase in lungs of septic mice. Our findings suggest that heparin is capable of suppressing the lethal response and acute lung injury associated with sepsis, and support the notion that heparin may be a potential therapeutic agent for the conditions associated with septic shock.
- Subjects :
- Acute Lung Injury mortality
Animals
Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents therapeutic use
Disease Models, Animal
Heparin pharmacology
Interleukin-1beta blood
Interleukin-6 blood
Lipopolysaccharides
Lung drug effects
Lung metabolism
Lung pathology
Male
Malondialdehyde metabolism
Mice
Mice, Inbred C57BL
NF-kappa B metabolism
Peroxidase antagonists & inhibitors
Sepsis mortality
Shock, Septic metabolism
Shock, Septic pathology
Tumor Necrosis Factor-alpha blood
p38 Mitogen-Activated Protein Kinases metabolism
src-Family Kinases metabolism
Acute Lung Injury drug therapy
Heparin therapeutic use
Inflammation drug therapy
Sepsis drug therapy
Shock, Septic drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2576
- Volume :
- 35
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 22782595
- Full Text :
- https://doi.org/10.1007/s10753-012-9503-0