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The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS.
- Source :
-
Trends in biochemical sciences [Trends Biochem Sci] 1990 Nov; Vol. 15 (11), pp. 425-30. - Publication Year :
- 1990
-
Abstract
- A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.
- Subjects :
- Amino Acid Sequence
Animals
Antiviral Agents therapeutic use
Drug Design
HIV Protease genetics
Humans
Molecular Sequence Data
Pepsin A genetics
Protease Inhibitors chemistry
Protease Inhibitors therapeutic use
Protein Conformation
Acquired Immunodeficiency Syndrome drug therapy
Antiviral Agents chemistry
HIV Protease chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0968-0004
- Volume :
- 15
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Trends in biochemical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 2278102
- Full Text :
- https://doi.org/10.1016/0968-0004(90)90280-o