Screening rhodium metallopeptide libraries "on bead": asymmetric cyclopropanation and a solution to the enantiomer problem.

Authors :: Sambasivan R
Ball ZT
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2012 Aug 20; Vol. 51 (34), pp. 8568-72. Date of Electronic Publication: 2012 Jul 09.
Publication Year :: 2012
Abstract: Searching with a beady eye: A high-throughput, on-bead screen of rhodium metallopeptide catalysts was developed in a 96-well format for asymmetric cyclopropanation. Different sequences of natural L-amino acids have been identified that produce opposite product enantiomers. In addition to styrene derivatives, high enantioselectivity is observed for vinyl ether and vinyl amine derivatives.<br /> (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Amino Acid Sequence
Catalysis
Stereoisomerism
Cyclopropanes chemistry
Metalloproteins chemistry
Rhodium chemistry

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