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[Prognostic value of human papilloma virus DNA test in patients surgically treated for squamous cell cervical cancer].
- Source :
-
Voprosy onkologii [Vopr Onkol] 2012; Vol. 58 (2), pp. 233-7. - Publication Year :
- 2012
-
Abstract
- The human papilloma virus (HPV) DNA test was performed in paraffinized biopsy samples of iliac lymph nodes obtained from 98 patients with cervical cancer receiving therapy in N. N. Petrov Research Institute of Oncology in 2000 to 2007. The data obtained was compared to patients clinical course. The HPV DNA was detected in 29 of 98 patients samples (29,6%), 27 of those patients had metastatic disease. These patients had significantly higher metastasis rate than HPV DNA-negative patients (p < or = 0,05). The following highly oncogenic genotypes of HPV DNA were detected: type 16 in 15 patients (51,72%), type 18 in 4 patients (13,79%), type 31 in 5 patients (17,24%) and type 33 in 5 patients (17,24%). In all the cases the HPV type detected in the lymph nodes corresponded to the one detected in the primary tumor. The relapse-free survival of HPV DNA-positive patients with iliac lymph nodes metastases (N1) was significantly lower than in HPV DNA-negative patients (p < or = 0,05). The iliac lymph nodes HPV DNA detection had 43,6% sensitivity (95% CI: 28/60%) and 79,7% specificity (95% CI: 67/89%) for relapse prediction. The test results had diagnostic value in 65,3% of cases, the test was false-negative in 56,4% and false-positive in 20,3% of cases.
- Subjects :
- Adult
Aged
Alphapapillomavirus genetics
Carcinoma, Squamous Cell secondary
Disease-Free Survival
False Negative Reactions
False Positive Reactions
Female
Humans
Middle Aged
Papillomavirus Infections virology
Polymerase Chain Reaction
Predictive Value of Tests
Prognosis
Sensitivity and Specificity
Uterine Cervical Neoplasms pathology
Vaginal Smears
Alphapapillomavirus isolation & purification
Carcinoma, Squamous Cell surgery
Carcinoma, Squamous Cell virology
DNA, Viral isolation & purification
Papillomavirus Infections complications
Uterine Cervical Neoplasms surgery
Uterine Cervical Neoplasms virology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0507-3758
- Volume :
- 58
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Voprosy onkologii
- Publication Type :
- Academic Journal
- Accession number :
- 22774530