Does the level of serum antimüllerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging?

Objective: To determine possible prediction of regular menses with aging in anovulatory women with polycystic ovary syndrome (PCOS).
Design: Cohort.
Setting: Academic practice.
Patient(s): A total of 54 anovulatory women with PCOS and 28 age- and weight-matched control subjects.
Intervention(s): Blood and ovarian ultrasound at baseline and after 5 years. MAJOR OUTCOME MEASURE(S): Serum antimüllerian hormone (AMH), gonadotropins, androgens, insulin sensitivity, and ovarian ultrasound.
Result(s): After 5 years, there was a significant decrease in AMH in women with PCOS and control subjects (10 of 54 anovulatory women became ovulatory after 5 years). There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH ≤ 4 ng/mL was associated with ovulatory function.
Conclusion(s): Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS.
(Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)