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Synthesis and 1H-NMR studies of alpha-deuterated analogues of des-Trp1, Nle12-human minigastrin.
- Source :
-
Biopolymers [Biopolymers] 1990; Vol. 30 (7-8), pp. 847-54. - Publication Year :
- 1990
-
Abstract
- Three analogues of the tridecapeptide amide H-Leu-(Glu)5-Ala-Tyr-Gly-Nle-Asp-Phe-NH2 were synthetized with alpha-deuterated glutamate residues in specific positions in order to assign unambiguously the 1H nmr spectrum of the parent peptide in water and in water-trifluoroethanol mixtures. The synthetic route is described and the assignment illustrated. A previous, tentative assignment based solely on indirect evidence [Mammi, S., Mammi, N. J. & Peggion, E. (1988) Biochemistry 27, 1374-1379] was partially modified.
Details
- Language :
- English
- ISSN :
- 0006-3525
- Volume :
- 30
- Issue :
- 7-8
- Database :
- MEDLINE
- Journal :
- Biopolymers
- Publication Type :
- Academic Journal
- Accession number :
- 2275983
- Full Text :
- https://doi.org/10.1002/bip.360300719