Back to Search
Start Over
Intranasal application of secretin, similarly to intracerebroventricular administration, influences the motor behavior of mice probably through specific receptors.
- Source :
-
Journal of molecular neuroscience : MN [J Mol Neurosci] 2012 Nov; Vol. 48 (3), pp. 558-64. Date of Electronic Publication: 2012 Jul 01. - Publication Year :
- 2012
-
Abstract
- Secretin and its receptors show wide distribution in the central nervous system. It was demonstrated previously that intravenous (i.v.) and intracerebroventricular (i.c.v.) application of secretin influenced the behavior of rat, mouse, and human. In our previous experiment, we used a special animal model, Japanese waltzing mice (JWM). These animals run around without stopping (the ambulation distance is very limited) and they do not bother with their environment. The i.c.v. secretin attenuated this hyperactive repetitive movement. In the present work, the effect of i.c.v. and intranasal (i.n.) application of secretin was compared. We have also looked for the presence of secretin receptors in the brain structures related to motor functions. Two micrograms of i.c.v. secretin improved the horizontal movement of JWM, enhancing the ambulation distance. It was nearly threefold higher in treated than in control animals. The i.n. application of secretin to the left nostril once or twice a day or once for 3 days more effectively enhanced the ambulation distance than i.c.v. administration. When secretin was given twice a day for 3 days it had no effect. Secretin did not improve the explorative behavior (the rearing), of JWM. With the use of in situ hybridization, we have found very dense secretin receptor labeling in the cerebellum. In the primary motor cortex and in the striatum, only a few labeled cells were seen. It was supposed that secretin exerted its effect through specific receptors, mainly present in the cerebellum.
- Subjects :
- Administration, Intranasal
Animals
Cerebellum chemistry
Cerebellum drug effects
Corpus Striatum chemistry
Drug Evaluation, Preclinical
Female
Hyperkinesis drug therapy
Hyperkinesis genetics
In Situ Hybridization
Injections, Intraventricular
Male
Mice
Mice, Neurologic Mutants
Motor Activity physiology
Motor Cortex chemistry
Nerve Tissue Proteins agonists
Nerve Tissue Proteins analysis
Nerve Tissue Proteins physiology
Rats
Rats, Sprague-Dawley
Receptors, G-Protein-Coupled agonists
Receptors, G-Protein-Coupled analysis
Receptors, G-Protein-Coupled physiology
Receptors, Gastrointestinal Hormone agonists
Receptors, Gastrointestinal Hormone analysis
Receptors, Gastrointestinal Hormone physiology
Secretin administration & dosage
Secretin therapeutic use
Exploratory Behavior drug effects
Motor Activity drug effects
Secretin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1559-1166
- Volume :
- 48
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of molecular neuroscience : MN
- Publication Type :
- Academic Journal
- Accession number :
- 22752505
- Full Text :
- https://doi.org/10.1007/s12031-012-9839-9