Comparing gray and white matter fMRI activation using asymmetric spin echo spiral.

Recent developments have shown that it is possible to detect functional magnetic resonance imaging (fMRI) activation in white matter (WM). Enhanced sensitivity to WM fMRI signals has been associated with the asymmetric spin echo (ASE) spiral sequence. The ASE spiral sequence produces three consecutive images that have equal blood-oxygen level-dependent (BOLD) contrast but increasing T(2) contrast. The current study evaluated whether ASE spiral sensitivity differed between white and gray matter in the corpus callosum, superior parietal lobes, cingulate gyrus, and inferior frontal lobes. Contrast and noise were compared across the three images for each region. Results showed increasing gains in functional contrast in both white and gray matter as a function of T(2) contrast. The third image, with the most T(2) contrast, showed the largest increase in contrast, while changes in noise were maintained. The results suggest that ASE spiral increases fMRI sensitivity globally through the addition of T(2) weighted contrast.
(Crown Copyright © 2012. Published by Elsevier B.V. All rights reserved.)