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Identification and biological activities of bryostatins from Japanese bryozoan.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2012; Vol. 76 (5), pp. 1041-3. Date of Electronic Publication: 2012 May 07. - Publication Year :
- 2012
-
Abstract
- Six bryostatins were isolated from Japanese bryozoan by evaluating their binding to the C1B domain of protein kinase Cδ (PKCδ). Structure-activity studies of bryostatins 4, 10, and 14 suggested that the ester group at C20 was not necessary for binding to and activating PKCδ. These bryostatins showed significant anti-tumor-promoting activity in induction tests with the Epstein-Barr virus early antigen.
- Subjects :
- Animals
Antigens, Viral metabolism
Antineoplastic Agents pharmacology
B-Lymphocytes metabolism
B-Lymphocytes virology
Bryostatins pharmacology
Enzyme Activation
Herpesvirus 4, Human physiology
Humans
Isoenzymes chemistry
Isoenzymes metabolism
Japan
Protein Binding
Protein Kinase C-delta chemistry
Protein Structure, Tertiary
Structure-Activity Relationship
Antineoplastic Agents isolation & purification
B-Lymphocytes drug effects
Bryostatins isolation & purification
Bryozoa chemistry
Protein Kinase C-delta metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1347-6947
- Volume :
- 76
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22738985
- Full Text :
- https://doi.org/10.1271/bbb.120026