Back to Search
Start Over
ε-Viniferin is more effective than its monomer resveratrol in improving the functions of vascular endothelial cells and the heart.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2012; Vol. 76 (5), pp. 954-60. Date of Electronic Publication: 2012 May 07. - Publication Year :
- 2012
-
Abstract
- The present study compared the effects of resveratrol and its dimer ε-viniferin on vascular endothelial cells (VECs) functions, and on the blood pressure and cardiac mass of spontaneously hypertensive rats (SHRs). Treatment of VECs with these compounds enhanced cell proliferation via nitric oxide generation and protected the cells from oxidative stress by suppressing increases in intracellular oxygen species. ε-Viniferin was more potent than resveratrol in most of these effects. ε-Viniferin, but not resveratrol inhibited angiotensin-converting enzyme activity in vitro. Three weeks of ε-viniferin treatment (5 mg/kg) reduced the systolic blood pressure and improved the whole cardiac mass and left ventricle mass indexes in SHRs. In contrast, resveratrol administration (2.5 mg/kg) failed to lower the blood pressure and significantly improve these mass indexes. These data suggest that ε-viniferin as well as resveratrol may be involved in protecting the functions of VECs and the heart.
- Subjects :
- Angiotensin-Converting Enzyme Inhibitors pharmacology
Animals
Blood Pressure drug effects
Cell Proliferation drug effects
Cell Survival drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Endothelial Cells metabolism
Endothelial Cells pathology
Male
Nitric Oxide biosynthesis
Organ Size drug effects
Oxidative Stress drug effects
Peptidyl-Dipeptidase A metabolism
Rats
Rats, Inbred SHR
Rats, Wistar
Reactive Oxygen Species antagonists & inhibitors
Resveratrol
Swine
Antioxidants pharmacology
Benzofurans pharmacology
Endothelial Cells drug effects
Myocardium pathology
Stilbenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1347-6947
- Volume :
- 76
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22738966
- Full Text :
- https://doi.org/10.1271/bbb.110975