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Outcome of children with refractory anaemia with excess of blast (RAEB) and RAEB in transformation (RAEB-T) in the Japanese MDS99 study.
- Source :
-
British journal of haematology [Br J Haematol] 2012 Sep; Vol. 158 (5), pp. 657-61. Date of Electronic Publication: 2012 Jun 26. - Publication Year :
- 2012
-
Abstract
- We report the outcome of 16 children with refractory anaemia with excess of blasts (RAEB; n = 4) and RAEB in transformation (RAEB-T; n = 12) following induction therapy with etoposide, cytarabine and mitoxantrone (ECM) prior to haematopoietic stem cell transplantation (HSCT). The median observation period was 77 months (range 5-123). Complete remission rate was 81% following induction; no toxic deaths occurred. Eight-year event-free survival and overall survival was 50% and 56%, respectively. None of the three patients with a complex karyotype survived, suggesting karyotype is a crucial prognostic factor for survival. This study indicates the safety and high remission rate of ECM and high survival rates after HSCT for paediatric RAEB and RAEB-T.<br /> (© 2012 Blackwell Publishing Ltd.)
- Subjects :
- Anemia, Refractory, with Excess of Blasts pathology
Cell Transformation, Neoplastic pathology
Child
Cytarabine administration & dosage
Etoposide administration & dosage
Hematopoietic Stem Cell Mobilization methods
Hematopoietic Stem Cell Transplantation
Humans
Kaplan-Meier Estimate
Mitoxantrone administration & dosage
Remission Induction methods
Treatment Outcome
Anemia, Refractory, with Excess of Blasts therapy
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 158
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 22734597
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2012.09210.x