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Unleashing a "true" pSer-mimic in the cell.
- Source :
-
Chemistry & biology [Chem Biol] 2012 Jun 22; Vol. 19 (6), pp. 666-7. - Publication Year :
- 2012
-
Abstract
- In this issue of Chemistry & Biology, Arrendale and coworkers demonstrate a new prodrug strategy for intracellular delivery of an α, α-(difluoromethylene)phosphonate phosphoserine mimic. The deprotected pseudo-phosphopeptide releases the pro-apoptotic FOXO3a-transcription factor from its 14-3-3-adaptor protein complex, resulting in leukemic cell death.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-1301
- Volume :
- 19
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Chemistry & biology
- Publication Type :
- Academic Journal
- Accession number :
- 22726679
- Full Text :
- https://doi.org/10.1016/j.chembiol.2012.06.005