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Growth hormone response to a bolus injection of 1-44 growth-hormone-releasing hormone in very short children with intrauterine onset of growth failure.
- Source :
-
Hormone research [Horm Res] 1990; Vol. 33 (5), pp. 161-5. - Publication Year :
- 1990
-
Abstract
- The release of growth hormone (GH) during the 120 min following a bolus venous injection of 1-44 GH-releasing hormone (GHRH) 2 micrograms/kg was studied in 52 prepubertal children aged 8.4 +/- 2.1 years, having a nonfamilial growth deficiency of prenatal onset (-3.26 +/- 1.13 SDS at birth, -3.22 +/- 0.88 SDS at the time of study) and a normal response to conventional GH stimulation tests. GH release reached a peak level of 96.1 +/- 60.2 microU/ml, being significantly higher than that found in 68 non-GH-deficient very short children whose growth failure had a postnatal onset, and not significantly correlated with the response to conventional tests. 26 of the 52 intrauterine growth retardation (IUGR) patients were re-tested with GHRH in similar conditions after 6-12 months of daily subcutaneous injections of GH and 2 days without. They reached at the second test a peak plasma GH level of 91.7 +/- 56.1 microU/ml, not different from their response to the first test. These data could be taken into consideration for long-term studies of the clinical effects of GH in IUGR children with persisting severe growth deficiency.
- Subjects :
- Child
Child, Preschool
Female
Fetal Growth Retardation drug therapy
Growth Hormone therapeutic use
Humans
Injections, Intravenous
Male
Pituitary Gland drug effects
Pituitary Gland metabolism
Fetal Growth Retardation metabolism
Growth Disorders drug therapy
Growth Hormone metabolism
Growth Hormone-Releasing Hormone pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0301-0163
- Volume :
- 33
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Hormone research
- Publication Type :
- Academic Journal
- Accession number :
- 2272607
- Full Text :
- https://doi.org/10.1159/000181502