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Aortic calcification and femoral bone density are independently associated with left ventricular mass in patients with chronic kidney disease.
- Source :
-
PloS one [PLoS One] 2012; Vol. 7 (6), pp. e39241. Date of Electronic Publication: 2012 Jun 18. - Publication Year :
- 2012
-
Abstract
- Background: Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown. We assessed the relationship between vascular calcification, femoral bone density and left ventricular mass in patients with stage 3 non-diabetic chronic kidney disease in a cross-sectional observational study.<br />Methodology and Principal Findings: A total of 120 patients were recruited (54% male, mean age 55 ± 14 years, mean glomerular filtration rate 50 ± 13 ml/min/1.73 m(2)). Abdominal aortic calcification was assessed using lateral lumbar spine radiography and was present in 48%. Mean femoral Z-score measured using dual energy x-ray absorptiometry was 0.60 ± 1.06. Cardiovascular magnetic resonance imaging was used to determine left ventricular mass. One patient had left ventricular hypertrophy. Subjects with aortic calcification had higher left ventricular mass compared to those without (56 ± 16 vs. 48 ± 12 g/m(2), P = 0.002), as did patients with femoral Z-scores below zero (56 ± 15 vs. 49 ± 13 g/m(2), P = 0.01). In univariate analysis presence of aortic calcification correlated with left ventricular mass (r = 0.32, P = 0.001); mean femoral Z-score inversely correlated with left ventricular mass (r = -0.28, P = 0.004). In a multivariate regression model that included presence of aortic calcification, mean femoral Z-score, gender and 24-hour systolic blood pressure, 46% of the variability in left ventricular mass was explained (P<0.001).<br />Conclusions: In patients with stage 3 non-diabetic chronic kidney disease, lower mean femoral Z-score and presence of aortic calcification are independently associated with increased left ventricular mass. Further research exploring the pathophysiology that underlies these relationships is warranted.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Calcinosis diagnostic imaging
Female
Humans
Hypertrophy, Left Ventricular pathology
Male
Middle Aged
Radiography
Renal Insufficiency, Chronic diagnosis
Renal Insufficiency, Chronic pathology
Reproducibility of Results
Young Adult
Aorta, Abdominal pathology
Bone Density
Calcinosis complications
Femur diagnostic imaging
Hypertrophy, Left Ventricular complications
Hypertrophy, Left Ventricular diagnosis
Renal Insufficiency, Chronic complications
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 7
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 22723973
- Full Text :
- https://doi.org/10.1371/journal.pone.0039241