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The role of pharmacogenomics in metastatic renal cell carcinoma.
- Source :
-
Cancer metastasis reviews [Cancer Metastasis Rev] 2012 Sep; Vol. 31 Suppl 1, pp. S29-32. - Publication Year :
- 2012
-
Abstract
- Pharmacogenomics is the study of how variation in the genetic background affects an individual's response to a specific drug and/or its metabolism. Using knowledge about the genes which produce the enzymes that metabolize a specific drug, a physician may decide to raise or lower the dose, or even change to a different drug. Targeted therapy with tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors has led to a substantial improvement in the standard of care for patients with advanced or metastatic renal cell carcinoma (RCC). Although few studies have identified biomarkers that predict the response of targeted drugs in the treatment of metastatic RCC, some associations have been found. Several studies have identified genetic polymorphisms with implications in the pharmacokinetics and/or pharmacodynamics of TKIs and mTOR inhibitors and which are associated with a prolonged progression-free survival and/or overall survival in patients with metastatic RCC. Among the genes of interest, we should consider IL8, FGFR2, VEGFA, FLT4, and NR1I2. In this review, we discuss single nucleotide polymorphisms (SNPs) associated with outcome and toxicity following targeted therapies and provide recommendations for future trials to facilitate the use of SNPs in personalized therapy for this disease.
- Subjects :
- Carcinoma, Renal Cell metabolism
Carcinoma, Renal Cell pathology
Drug Delivery Systems
Humans
Kidney Neoplasms metabolism
Kidney Neoplasms pathology
Neoplasm Metastasis
Pharmacogenetics
Polymorphism, Single Nucleotide
Biomarkers, Tumor metabolism
Carcinoma, Renal Cell drug therapy
Carcinoma, Renal Cell genetics
Kidney Neoplasms drug therapy
Kidney Neoplasms genetics
Protein Kinase Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7233
- Volume :
- 31 Suppl 1
- Database :
- MEDLINE
- Journal :
- Cancer metastasis reviews
- Publication Type :
- Academic Journal
- Accession number :
- 22723081
- Full Text :
- https://doi.org/10.1007/s10555-012-9356-x