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DNA vaccines encoding proteins from wild-type and attenuated canine distemper virus protect equally well against wild-type virus challenge.
- Source :
-
Archives of virology [Arch Virol] 2012 Oct; Vol. 157 (10), pp. 1887-96. Date of Electronic Publication: 2012 Jun 20. - Publication Year :
- 2012
-
Abstract
- Immunity induced by DNA vaccines containing the hemagglutinin (H) and nucleoprotein (N) genes of wild-type and attenuated canine distemper virus (CDV) was investigated in mink (Mustela vison), a highly susceptible natural host of CDV. All DNA-immunized mink seroconverted, and significant levels of virus-neutralizing (VN) antibodies were present on the day of challenge with wild-type CDV. The DNA vaccines also primed the cell-mediated memory responses, as indicated by an early increase in the number of interferon-gamma (IFN-γ)-producing lymphocytes after challenge. Importantly, the wild-type and attenuated CDV DNA vaccines had a long-term protective effect against wild-type CDV challenge. The vaccine-induced immunity induced by the H and N genes from wild-type CDV and those from attenuated CDV was comparable. Because these two DNA vaccines were shown to protect equally well against wild-type virus challenge, it is suggested that the genetic/antigenic heterogeneity between vaccine strains and contemporary wild-type strains are unlikely to cause vaccine failure.
- Subjects :
- Animals
Antibodies, Neutralizing blood
Antibodies, Neutralizing immunology
Antibodies, Viral blood
Antibodies, Viral immunology
Distemper immunology
Distemper Virus, Canine genetics
Female
Hemagglutinins, Viral genetics
Immunization
Mink immunology
Nucleoproteins genetics
Vaccines, Attenuated administration & dosage
Vaccines, Attenuated genetics
Vaccines, Attenuated immunology
Vaccines, DNA genetics
Vaccines, DNA immunology
Viral Vaccines genetics
Viral Vaccines immunology
Distemper prevention & control
Distemper Virus, Canine immunology
Hemagglutinins, Viral immunology
Nucleoproteins immunology
Vaccines, DNA administration & dosage
Viral Vaccines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1432-8798
- Volume :
- 157
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Archives of virology
- Publication Type :
- Academic Journal
- Accession number :
- 22714870
- Full Text :
- https://doi.org/10.1007/s00705-012-1375-y