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Variable fragments of heavy chain antibodies (VHHs): a new magic bullet molecule of medicine?
- Source :
-
Postepy higieny i medycyny doswiadczalnej (Online) [Postepy Hig Med Dosw (Online)] 2012 Jun 14; Vol. 66, pp. 348-58. Date of Electronic Publication: 2012 Jun 14. - Publication Year :
- 2012
-
Abstract
- Serum of animals belonging to the Camelidae family (camels and llamas) contains fully active antibodies that are naturally devoid of light chains. Variable domains derived from heavy chain antibodies (hcAb) called VHHs or nanobodies™ can bind antigens as effectively as full-length antibodies and are easy to clone and express. Because of their potential, VHHs are being intensively studied as potential therapeutic, diagnostic and imaging tools. The paper reviews the molecular background of heavy chain antibodies and describes methods of obtaining recombinant fragments of heavy chain antibodies as well as their therapeutic, diagnostic and other applications.
- Subjects :
- Animals
Antineoplastic Agents metabolism
Antineoplastic Agents therapeutic use
Autoimmune Diseases drug therapy
Camelids, New World
Chromatography, Affinity methods
Communicable Diseases drug therapy
Fishes
Hematologic Diseases drug therapy
Humans
Immunoglobulin Fragments chemistry
Immunoglobulin Fragments isolation & purification
Immunoglobulin Heavy Chains chemistry
Immunoglobulin Heavy Chains isolation & purification
Single-Domain Antibodies chemistry
Single-Domain Antibodies isolation & purification
Single-Domain Antibodies therapeutic use
Species Specificity
Immunoglobulin Fragments therapeutic use
Immunoglobulin Heavy Chains therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1732-2693
- Volume :
- 66
- Database :
- MEDLINE
- Journal :
- Postepy higieny i medycyny doswiadczalnej (Online)
- Publication Type :
- Academic Journal
- Accession number :
- 22706121
- Full Text :
- https://doi.org/10.5604/17322693.1000334