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[Protocol for administration of trastuzumab based on cardiac function].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2012 Jun; Vol. 39 (6), pp. 915-9. - Publication Year :
- 2012
-
Abstract
- We analyzed 7 patients with breast cancer who suffered from trastuzumab-associated cardiac dysfunction. Left ventricular ejection fraction (EF) was calculated by M-mode echocardiography. We propose a protocol for the administration of trastuzumab based on EF in the clinical courses of the 7 patients and the literatures concernig trastuzumab. If the EF is ≥60%, an echocardiography is performed every 3 months during trastuzumab therapy. If the EF is ≥53% and ≤60%, an echocardiography is performed every 2 months. If the EF is ≤53%, an echocardiography is performed more frequently. If the EF decreases by ≥10% from its previous level, an echocardiography is performed after 3 weeks. Also, trastuzumab is withheld when the EF falls to ≤45%. When the EF falls to ≤40%, the standard treatment for congestive heart failure is initiated. An echocardiography is performed every 2 weeks after trastuzumab is withheld. Trastuzumab therapy can be resumed if the EF improves to ≥50%.
- Subjects :
- Adult
Aged, 80 and over
Antibodies, Monoclonal, Humanized therapeutic use
Female
Humans
Middle Aged
Trastuzumab
Ultrasonography
Ventricular Dysfunction, Left diagnostic imaging
Ventricular Dysfunction, Left physiopathology
Antibodies, Monoclonal, Humanized adverse effects
Breast Neoplasms drug therapy
Ventricular Dysfunction, Left chemically induced
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 39
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 22705685