Back to Search
Start Over
Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells.
- Source :
-
Molecular biology reports [Mol Biol Rep] 2012 Sep; Vol. 39 (9), pp. 8621-8. Date of Electronic Publication: 2012 Jun 15. - Publication Year :
- 2012
-
Abstract
- Bisphenol A (BPA) is an estrogenic environmental toxin widely used for the production of plastics. Human frequent exposure to this chemical has been proposed to be a potential public health risk. The objective of this study was to assess the effects of BPA on DNA methylation of imprinting genes in fetal mouse germ cell. Pregnant mice were treated with BPA at doses of 0, 40, 80 and 160 μg BPA/kg body weight/day from 0.5 day post coitum. DNA methylation of imprinting genes, Igf2r, Peg3 and H19, was decreased with the increase of BPA concentration in fetal mouse germ cells (p < 0.01).The relative mRNA levels of Nobox were lower in BPA-treated group compared to control (BPA free) in female fetal germ cells, but in male fetal germ cells, a significant higher in Nobox expression was observed in BPA-treated group compared to control. Decreased mRNA expression of specific meiotic genes including Stimulated by Stra8 and Dazl were obtained in the female fetal germ cells. In conclusion, BPA exposure can affect the DNA methylation of imprinting genes in fetal mouse germ cells.
- Subjects :
- Air Pollutants, Occupational pharmacology
Animals
Benzhydryl Compounds
CpG Islands
Environmental Exposure
Female
Gene Expression Regulation, Developmental drug effects
Kruppel-Like Transcription Factors genetics
Male
Mice
Phenols pharmacology
Pregnancy
Receptor, IGF Type 2 genetics
Receptors, Estrogen genetics
Air Pollutants, Occupational toxicity
DNA Methylation drug effects
Fetus drug effects
Genomic Imprinting drug effects
Germ Cells drug effects
Germ Cells metabolism
Phenols toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4978
- Volume :
- 39
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Molecular biology reports
- Publication Type :
- Academic Journal
- Accession number :
- 22699882
- Full Text :
- https://doi.org/10.1007/s11033-012-1716-7