Role of signal-to-cutoff ratios in hepatitis C virus antibody detection.

Authors :: Moretti M
Pieretti B
Masucci A
Sisti D
Rocchi M
Delprete E
Source :: Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2012 Aug; Vol. 19 (8), pp. 1329-31. Date of Electronic Publication: 2012 Jun 13.
Publication Year :: 2012
Abstract: We reviewed results from 12,800 samples tested for hepatitis C virus (HCV) antibody detection in our laboratory by screening (Ortho chemiluminescence immunoassay [CIA]) and supplemental tests (Chiron recombinant immunoblot assay [RIBA]). We found that a signal-to-cutoff (S/Co) ratio of 10.3 was, in our setting, the most efficient cutoff point to improve the diagnostic algorithm of HCV infection.