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Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study.
- Source :
-
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2012 Aug; Vol. 130 (2), pp. 332-42.e10. Date of Electronic Publication: 2012 Jun 12. - Publication Year :
- 2012
-
Abstract
- Patients with severe or difficult-to-treat asthma are an understudied population but account for considerable asthma morbidity, mortality, and costs. The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study was a large, 3-year, multicenter, observational cohort study of 4756 patients (n=3489 adults ≥ 18 years of age, n=497 adolescents 13-17 years of age, and n=770 children 6-12 years of age) with severe or difficult-to-treat asthma. TENOR's primary objective was to characterize the natural history of disease in this cohort. Data assessed semiannually and annually included demographics, medical history, comorbidities, asthma control, asthma-related health care use, medication use, lung function, IgE levels, self-reported asthma triggers, and asthma-related quality of life. We highlight the key findings and clinical implications from more than 25 peer-reviewed TENOR publications. Regardless of age, patients with severe or difficult-to-treat asthma demonstrated high rates of health care use and substantial asthma burden despite receiving multiple long-term controller medications. Recent exacerbation history was the strongest predictor of future asthma exacerbations. Uncontrolled asthma, as defined by the 2007 National Heart, Lung, and Blood Institute guidelines' impairment domain, was highly prevalent and predictive of future asthma exacerbations; this assessment can be used to identify high-risk patients. IgE and allergen sensitization played a role in the majority of severe or difficult-to-treat asthmatic patients.<br /> (Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Age Factors
Allergens immunology
Anti-Asthmatic Agents administration & dosage
Asthma epidemiology
Asthma physiopathology
Canada epidemiology
Child
Child, Preschool
Cohort Studies
Female
Humans
Immunoglobulin E blood
Immunoglobulin E immunology
Lung drug effects
Lung physiopathology
Male
Odds Ratio
Practice Guidelines as Topic
Quality of Life
Respiratory Function Tests
Severity of Illness Index
Sex Factors
Treatment Outcome
United States epidemiology
Anti-Asthmatic Agents therapeutic use
Asthma diagnosis
Asthma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6825
- Volume :
- 130
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of allergy and clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 22694932
- Full Text :
- https://doi.org/10.1016/j.jaci.2012.04.014