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[Multidrug-resistant Klebsiella pneumoniae, predisposing factors and associated mortality in a tertiary-care hospital in Colombia].
- Source :
-
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia [Rev Chilena Infectol] 2012 Apr; Vol. 29 (2), pp. 175-82. - Publication Year :
- 2012
-
Abstract
- Introduction: Bacterial resistance to antibiotics is a serious public health problem that is increasing worldwide. Resistant (R) Klebsiella pneumoniae is one of the main pathogens isolated in nosocomial infections. The aim of this study was to explore risk factors associated with the acquisition of infection by R-K. pneumoniae and mortality.<br />Methods: Prospective cohort study conducted in a hospital of high complexity of Medellin, October/2009-April/2010. The exposed group was defined as patients infected with R-K. pneumoniae (producing b-lactamases or carbapenemases). In order to identify risk factors associated with infection by R-K. pneumoniae and 30 day mortality, logistic regression and Cox proportional hazards regression were used.<br />Results: 243 patients were included in the study, 84 infected with R-K. pneumoniae and 159 infected with susceptible K. pneumoniae. Female sex (OR = 2.51 95% 1.37 to 4.6), the co-existence of cardiovascular disease (OR = 2.13 95% CI 1.14 to 3.99), previous use of ceftriaxone (OR = 9.52 95% CI 2.63 to 34.46) and carbapenems (OR = 4.23 95% CI 2.41 to 7.42) were risk factors associated to infection with R-K. pneumoniae. Some predictors of mortality were malignant neoplasia (HR = 4.43 95% CI 2.13 to 9.22) and mechanical ventilation (HR = 3.81 95% CI 1.99 to 7.28). There was no difference in 30-day mortality when comparing patients in both groups.<br />Conclusions: Female gender, cardiovascular disease and previous use of antimicrobials were associated with infection by R-K. pneumoniae. Thirty-day mortality was similar in both groups of patients.
- Subjects :
- Adolescent
Adult
Colombia epidemiology
Cross Infection microbiology
Epidemiologic Methods
Female
Hospitals, University
Humans
Klebsiella Infections microbiology
Klebsiella pneumoniae enzymology
Klebsiella pneumoniae isolation & purification
Male
Middle Aged
Young Adult
beta-Lactamases metabolism
Cross Infection mortality
Drug Resistance, Multiple, Bacterial
Klebsiella Infections mortality
Klebsiella pneumoniae drug effects
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0716-1018
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia
- Publication Type :
- Academic Journal
- Accession number :
- 22689033
- Full Text :
- https://doi.org/10.4067/S0716-10182012000200009