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[Questionnaire survey on the change of asthmatic response, adverse events and product usability due to drug switching between name-brand and generic tulobuterol tapes].
- Source :
-
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Yakugaku Zasshi] 2012; Vol. 132 (5), pp. 617-27. - Publication Year :
- 2012
-
Abstract
- Aggravation of asthmatic response (asthmatic attack, 2 cases) and adverse events (tremor, 1 case) due to a switch from a brand-name tulobuterol tape to a generic tape were recently reported. These changes disappeared after reformulation from generic to the brand-name tape. To investigate this issue, we conducted a questionnaire survey on changes of asthmatic response, adverse events and product usability due to a switch between tulobuterol tapes. We identified 44 cases (18 from doctors, 26 from pharmacists) in which changes of asthmatic response or adverse events had occurred due to a switch between tulobuterol tapes. Aggravation of asthmatic response had occurred in 30 cases and adverse events in 21 cases due to switch from brand-name tulobuterol tape to generic tape. As regards change of product usability, we obtained 96 relevant responses (18 from doctors, 78 cases pharmacists), and the major response was that generic tulobuterol tape peeled off the skin more easily than did the brand-name tape (60 cases). These results suggest that changes of asthmatic response, adverse events and product usability should be carefully monitored when switching tulobuterol tapes.
- Subjects :
- Aged
Child, Preschool
Drugs, Generic pharmacokinetics
Female
Humans
Male
Patient Satisfaction statistics & numerical data
Permeability
Pharmacists statistics & numerical data
Physicians statistics & numerical data
Skin metabolism
Surveys and Questionnaires
Terbutaline administration & dosage
Terbutaline adverse effects
Terbutaline pharmacokinetics
Transdermal Patch
Asthma drug therapy
Drug Substitution adverse effects
Drug Utilization statistics & numerical data
Drugs, Generic administration & dosage
Drugs, Generic adverse effects
Terbutaline analogs & derivatives
Subjects
Details
- Language :
- Japanese
- ISSN :
- 1347-5231
- Volume :
- 132
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
- Publication Type :
- Academic Journal
- Accession number :
- 22687698
- Full Text :
- https://doi.org/10.1248/yakushi.132.617