Insulin-like growth factor-1 and central neurodegenerative diseases.

Authors :: Torres Aleman I
Source :: Endocrinology and metabolism clinics of North America [Endocrinol Metab Clin North Am] 2012 Jun; Vol. 41 (2), pp. 395-408, vii.
Publication Year :: 2012
Abstract: The previously undisputed neuroprotective role of insulin-like growth factor 1 (IGF-1) has been challenged by recent observations in IGF-1 receptor (IGF-1R) defective mutants. As new ligand-dependent and ligand-independent roles for IGF-1R are now emerging, new insights into the biologic role of brain IGF-1R and its connection with serum and brain IGF-1 function are urgently required. In the meantime, treatment of specific neurodegenerative diseases with IGF-1 may still be explored using adequate preclinical procedures.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)