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Mesenchymal stem cells as therapeutic agents of inflammatory and autoimmune diseases.
- Source :
-
Current opinion in biotechnology [Curr Opin Biotechnol] 2012 Dec; Vol. 23 (6), pp. 978-83. Date of Electronic Publication: 2012 Jun 07. - Publication Year :
- 2012
-
Abstract
- Interest and expectations on therapies based on adult mesenchymal stem/stromal cells (MSCs) for inflammatory and autoimmune diseases have remarkably grown in recent years, supported by encouraging data demonstrating their immunomodulatory properties and therapeutic effects in experimental animal models. Despite extensive research, our knowledge on areas of importance for their clinical use such as the mechanism/s of action, the route, dosing and timing of administration, the cell fate and distribution in vivo, the safety and efficacy of allogeneic MSCs treatments, remain insufficient. A better understanding of MSCs biology is required to ensure that the therapeutic efficacy, as observed in animal models, can be successfully translated in clinical trials. Current situation and future directions will be discussed.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Autoimmune Diseases immunology
Cell Transformation, Neoplastic
Humans
Inflammation immunology
Mesenchymal Stem Cells pathology
Transplantation, Homologous
Treatment Outcome
Autoimmune Diseases therapy
Inflammation therapy
Mesenchymal Stem Cell Transplantation adverse effects
Mesenchymal Stem Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0429
- Volume :
- 23
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Current opinion in biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 22682584
- Full Text :
- https://doi.org/10.1016/j.copbio.2012.05.005