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Short-term clinico-radiographic response to super-selective intra-arterial cerebral infusion of Bevacizumab for the treatment of vestibular schwannomas in Neurofibromatosis type 2.
- Source :
-
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences [Interv Neuroradiol] 2012 Jun; Vol. 18 (2), pp. 127-32. Date of Electronic Publication: 2012 Jun 04. - Publication Year :
- 2012
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Abstract
- Neurofibromatosis type 2 (NF2) is an autosomal dominant syndrome with a prevalence of approximately 1 in 30,000. NF 2 is characterized by bilateral vestibular schwannomas, as well as meningiomas, ependymomas and gliomas. Currently, surgical resection and radiotherapy represent the mainstay of treatment, although new studies suggest a role for certain chemotherapeutic agents. Intravenous administration of Bevacizumab (Avastin, Genetech Pharmaceuticals) has been shown to be active in the treatment of vestibular schwannomas. The IV route of administration, however, carries a risk of known systemic side-effects such as bowel perforation, wound dehiscence and pulmonary embolism. In addition, the percentage of drug that reaches the tumor site may be restricted by the blood tumor barrier. This report describes the super-selective intra-arterial infusion of Bevacizumab following blood brain barrier disruption for the treatment of vestibular schwannomas in three patients with Neurofibromatosis type 2. It represents the first time such a technique has been performed for this disease. Additionally, this method of drug delivery may have important implications in the treatment of patients with vestibular schwannomas associated with Neurofibromatosis type 2.
- Subjects :
- Adult
Angiography, Digital Subtraction
Bevacizumab
Blood-Brain Barrier
Cerebral Angiography
Female
Humans
Infusions, Intra-Arterial
Magnetic Resonance Angiography
Male
Middle Aged
Treatment Outcome
Angiogenesis Inhibitors administration & dosage
Antibodies, Monoclonal, Humanized administration & dosage
Neurofibromatosis 2 complications
Neuroma, Acoustic drug therapy
Neuroma, Acoustic etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1591-0199
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 22681725
- Full Text :
- https://doi.org/10.1177/159101991201800201