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Reduced intensity allogeneic hematopoietic stem cell transplantation for MDS using tacrolimus/sirolimus-based GVHD prophylaxis.
- Source :
-
Leukemia research [Leuk Res] 2012 Sep; Vol. 36 (9), pp. 1152-6. Date of Electronic Publication: 2012 Jun 05. - Publication Year :
- 2012
-
Abstract
- We report a consecutive series of 59 patients with MDS who underwent reduced-intensity hematopoietic stem cell transplantation (RI-HSCT) with fludarabine/melphalan conditioning and tacrolimus/sirolimus-based GVHD prophylaxis. Two-year OS, EFS, and relapse incidences were 75.1%, 65.2%, and 20.9%, respectively. The cumulative incidence of non-relapse mortality at 100 days, 1 year, and 2 years was 3.4%, 8.5%, and 10.5%, respectively. The incidence of grade II-IV acute GVHD was 35.4%; grade III-IV was 18.6%. Forty of 55 evaluable patients developed chronic GVHD; of these 35 were extensive grade. This RI-HSCT protocol produces encouraging outcomes in MDS patients, and tacrolimus/sirolimus-based GVHD prophylaxis may contribute to that promising result.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Chemoprevention methods
Dose-Response Relationship, Drug
Drug Combinations
Female
Graft vs Host Disease epidemiology
Graft vs Host Disease etiology
Graft vs Host Disease mortality
Humans
Immunosuppressive Agents administration & dosage
Incidence
Male
Melphalan administration & dosage
Melphalan adverse effects
Middle Aged
Myelodysplastic Syndromes diagnosis
Myelodysplastic Syndromes drug therapy
Myelodysplastic Syndromes mortality
Retrospective Studies
Survival Analysis
Transplantation, Homologous
Vidarabine administration & dosage
Vidarabine analogs & derivatives
Young Adult
Graft vs Host Disease prevention & control
Hematopoietic Stem Cell Transplantation adverse effects
Hematopoietic Stem Cell Transplantation methods
Myelodysplastic Syndromes therapy
Sirolimus administration & dosage
Tacrolimus administration & dosage
Transplantation Conditioning methods
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5835
- Volume :
- 36
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Leukemia research
- Publication Type :
- Academic Journal
- Accession number :
- 22677229
- Full Text :
- https://doi.org/10.1016/j.leukres.2012.04.022