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Genetic alterations in a primary medullary thyroid carcinoma and its lymph node metastasis in a patient with 15 years follow-up.
- Source :
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Diagnostic pathology [Diagn Pathol] 2012 Jun 07; Vol. 7, pp. 63. Date of Electronic Publication: 2012 Jun 07. - Publication Year :
- 2012
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Abstract
- Background: Association between DNA alterations and clinical parameters as recurrence, survival or prognosis has been found in a variety of tumors. A clear association between Medullary Thyroid Carcinoma (MTC) and RET oncogene mutation has been accepted. Specifically M918T RET mutation represents the main genetic event in most cases of sporadic MTC (SMTC) and limited chromosomal alterations analyses have been performed.<br />Methods: In the present work, a comparative genomic hybridization (CGH) study was performed using DNA from a primary tumor in a M918T RET mutation-positive SMTC patient and from its lymph node metastasis to investigate additional genetic alterations. We studied a patient with 15 years of follow-up and persistence of disease, confirmed by periodical elevated serum calcitonin (CT) levels.<br />Results: Only 3 chromosomal imbalances were identified in the primary tumor, gain of 18p, and loss of 6p and 16p region, whereas 25 chromosomal imbalances were identified in the metastasis (9 gains and 16 losses).<br />Conclusion: The chromosomal changes 6p-, 16p-, 18p + could determine in part the oncogenic phenotype in the primary M918T RET positive tumor and probably related to persistence of high serum CT levels in this patient. The additional chromosomal changes observed could be related to the metastasis phenotype. We suggest that some genes mapped at 6p, 16p and 18p chromosomal regions, could act as genes associated to cancer and could be related to persistent SMTC and good prognosis.<br />Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1720753793691097.
- Subjects :
- Aged
Carcinoma, Neuroendocrine
Comparative Genomic Hybridization
Female
Follow-Up Studies
Humans
Lymphatic Metastasis genetics
Proto-Oncogene Proteins c-ret genetics
Thyroid Neoplasms pathology
Chromosomes, Human, Pair 16 genetics
Chromosomes, Human, Pair 18 genetics
Chromosomes, Human, Pair 6 genetics
Thyroid Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1746-1596
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Diagnostic pathology
- Publication Type :
- Academic Journal
- Accession number :
- 22676344
- Full Text :
- https://doi.org/10.1186/1746-1596-7-63