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Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria.
- Source :
-
Science (New York, N.Y.) [Science] 2012 Jun 08; Vol. 336 (6086), pp. 1321-5. Date of Electronic Publication: 2012 Jun 06. - Publication Year :
- 2012
-
Abstract
- The mammalian intestinal tract is colonized by trillions of beneficial commensal bacteria that are anatomically restricted to specific niches. However, the mechanisms that regulate anatomical containment remain unclear. Here, we show that interleukin-22 (IL-22)-producing innate lymphoid cells (ILCs) are present in intestinal tissues of healthy mammals. Depletion of ILCs resulted in peripheral dissemination of commensal bacteria and systemic inflammation, which was prevented by administration of IL-22. Disseminating bacteria were identified as Alcaligenes species originating from host lymphoid tissues. Alcaligenes was sufficient to promote systemic inflammation after ILC depletion in mice, and Alcaligenes-specific systemic immune responses were associated with Crohn's disease and progressive hepatitis C virus infection in patients. Collectively, these data indicate that ILCs regulate selective containment of lymphoid-resident bacteria to prevent systemic inflammation associated with chronic diseases.
- Subjects :
- Adult
Alcaligenes immunology
Alcaligenes isolation & purification
Animals
Bacterial Translocation
Crohn Disease immunology
Crohn Disease microbiology
Hepatitis C, Chronic immunology
Hepatitis C, Chronic microbiology
Humans
Immunity, Innate
Inflammation
Interleukins administration & dosage
Interleukins biosynthesis
Intestines microbiology
Leukocyte L1 Antigen Complex metabolism
Liver microbiology
Lymph Nodes immunology
Macaca mulatta
Mice
Mice, Inbred C57BL
Middle Aged
Spleen microbiology
Young Adult
Interleukin-22
Alcaligenes physiology
Interleukins immunology
Intestines immunology
Lymphocytes immunology
Lymphoid Tissue immunology
Lymphoid Tissue microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 336
- Issue :
- 6086
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 22674331
- Full Text :
- https://doi.org/10.1126/science.1222551