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Systemic lupus erythematosus, progressive multifocal leukoencephalopathy, and T-CD4+ lymphopenia.
- Source :
-
Clinical reviews in allergy & immunology [Clin Rev Allergy Immunol] 2012 Dec; Vol. 43 (3), pp. 302-7. - Publication Year :
- 2012
-
Abstract
- Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection caused by the reactivation of JC virus and occurs in patients with severe primary or secondary immunosuppression. Recently, PML is becoming relevant in autoimmune disorders, particularly in patients treated with biologic agents. However, systemic lupus erythematosus (SLE) appears to be associated with susceptibility to PML that cannot be entirely explained by the immunosuppressive therapy. The authors present two patients with the diagnosis of SLE and PML: One had a heavy immunosuppressive therapy history, and the other had never experienced biologic or cytotoxic therapeutics. Both patients had a profound T-CD4+ lymphopenia during their clinical history. These two cases emphasize the importance of CD4+ lymphopenia in SLE patients with and without immunosuppressors regarding opportunistic infections.
- Subjects :
- Adult
Female
Humans
Middle Aged
Immunosuppressive Agents immunology
Leukoencephalopathy, Progressive Multifocal etiology
Leukoencephalopathy, Progressive Multifocal immunology
Lupus Erythematosus, Systemic etiology
Lupus Erythematosus, Systemic immunology
T-Lymphocytopenia, Idiopathic CD4-Positive complications
T-Lymphocytopenia, Idiopathic CD4-Positive immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0267
- Volume :
- 43
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical reviews in allergy & immunology
- Publication Type :
- Academic Journal
- Accession number :
- 22674017
- Full Text :
- https://doi.org/10.1007/s12016-012-8327-x