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Fractional carbon dioxide laser treatment to enhance skin permeation of ascorbic acid 2-glucoside with minimal skin disruption.
- Source :
-
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] [Dermatol Surg] 2012 Aug; Vol. 38 (8), pp. 1284-93. Date of Electronic Publication: 2012 Jun 05. - Publication Year :
- 2012
-
Abstract
- Background: Topical treatment with vitamin C has been used to treat photoaged skin and as a skin whitener, but no standard procedure exists for percutaneous delivery.<br />Objective: To compare skin histology and the permeation of ascorbic acid 2-glucoside (AA2G) after fractional and conventional carbon dioxide (CO(2) ) laser pretreatment.<br />Methods: The effect on porcine skin of treatment with different strengths of fractional and conventional CO(2) laser treatment was examined using scanning electron microscopy and transmission electron microscopy. Permeation of AA2G through porcine skin was tested in vitro using a Franz diffusion chamber. In vivo changes in fluorescein thiocyanate permeability in nude mice were examined using confocal laser scanning microscopy.<br />Results: Fractional CO(2) laser treatment with four or fewer passes caused less disruption than conventional laser treatment at the same fluence. AA2G permeation using four passes of fractional laser treatment was similar to that seen with conventional CO(2) laser treatment of the same fluence. Changes in permeability and in depth of permeation were higher with conventional than fractional laser treatment.<br />Conclusion: Fractional CO(2) laser treatment can cause similar transdermal delivery of AA2G to conventional laser treatment with less skin disruption and a different pattern of histologic change.<br /> (© 2012 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.)
- Subjects :
- Administration, Cutaneous
Animals
Ascorbic Acid administration & dosage
Ascorbic Acid pharmacokinetics
Female
In Vitro Techniques
Mice
Mice, Nude
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Skin radiation effects
Sus scrofa
Ascorbic Acid analogs & derivatives
Lasers, Gas
Skin ultrastructure
Skin Absorption radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4725
- Volume :
- 38
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
- Publication Type :
- Academic Journal
- Accession number :
- 22672633
- Full Text :
- https://doi.org/10.1111/j.1524-4725.2012.02454.x