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IgA anti-epidermal transglutaminase autoantibodies: a sensible and sensitive marker for diagnosis of dermatitis herpetiformis in adult patients.
- Source :
-
Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2013 Jul; Vol. 27 (7), pp. 836-41. Date of Electronic Publication: 2012 Jun 02. - Publication Year :
- 2013
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Abstract
- Background: Dermatitis herpetiformis (DH) is a rare gluten-sensitive blistering itchy skin disease, strictly related to coeliac disease (CD). Direct immunofluorescence, demonstrating IgA granular deposits localized either in the dermal papillae or along the dermo-epidermal junction, is currently the gold standard for diagnosis of DH. It has been shown that DH immunocomplexes contain epidermal transglutaminase (eTG) and that sera from patients with DH contain antibodies specifically directed against eTG.<br />Objectives: We studied the usefulness of serum eTG antibodies in discriminating between DH, CD and other gastrointestinal and dermatologic diseases.<br />Methods: eTG antibodies were tested in 308 adult patients' sera: 44 patients with untreated dermatitis herpetiformis (UDH), 99 patients with untreated coeliac disease (UCD), 70 dermatological controls and 95 gastrointestinal controls.<br />Results: In UDH eTG antibody levels were significantly higher than in DH patients on gluten-free diet, UCD, gastrointestinal controls and dermatological controls. In UCD eTG antibodies strongly correlated with tissue transglutaminase (tTG) antibodies, whereas in UDH no significant correlation was observed.<br />Conclusion: Serum IgA eTG antibody determination can efficiently distinguish UDH from other dermatological itchy diseases and is highly sensitive to gluten-free diet.<br /> (© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers blood
Celiac Disease blood
Celiac Disease immunology
Dermatitis Herpetiformis immunology
Epidermis immunology
Female
Humans
Male
Middle Aged
Sensitivity and Specificity
Young Adult
Autoantibodies blood
Autoantibodies immunology
Dermatitis Herpetiformis blood
Dermatitis Herpetiformis diagnosis
Immunoglobulin A immunology
Transglutaminases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-3083
- Volume :
- 27
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of the European Academy of Dermatology and Venereology : JEADV
- Publication Type :
- Academic Journal
- Accession number :
- 22672004
- Full Text :
- https://doi.org/10.1111/j.1468-3083.2012.04586.x