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Distribution of nonapeptide systems in the forebrain of an African cichlid fish, Astatotilapia burtoni.
- Source :
-
Journal of chemical neuroanatomy [J Chem Neuroanat] 2012 Jul; Vol. 44 (2), pp. 86-97. Date of Electronic Publication: 2012 Jun 02. - Publication Year :
- 2012
-
Abstract
- Nonapeptides and their receptors have important functions in mediating social behavior across vertebrates. Where these nonapeptides are synthesized in the brain has been studied extensively in most vertebrate lineages, yet we know relatively little about the neural distribution of nonapeptide receptors outside of mammals. As nonapeptides play influential roles in behavioral regulation in all vertebrates, including teleost fish, we mapped the distributions of the receptors for arginine vasotocin (AVT; homolog of arginine vasopressin) and isotocin (IST; homolog of oxytocin/mesotocin) throughout the forebrain of Astatotilapia burtoni, an African cichlid fish with behavioral phenotypes that are plastic and reversible based on the immediate social environment. We characterized the distribution of the AVT V1a2 receptor (V1aR) and the IST receptor (ITR) using both immunohistochemistry for protein detection and in situ hybridization for mRNA detection, as well as AVT and IST using immunohistochemistry. Expression of the neuropeptide receptors was widely distributed throughout the fore- and midbrain, including the proposed teleost homologs of the mammalian amygdala complex, striatum, hypothalamus, and ventral tegmental area. We conclude that although the location of nonapeptide synthesis is restricted compared to tetrapod vertebrates, the distribution of nonapeptide receptors is highly conserved across taxa. Our results significantly extend our knowledge of where nonapeptides act in the brains of teleosts to mediate social transitions and behavior.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Chickens
Humans
Immunohistochemistry
In Situ Hybridization
Male
Mice
Neuronal Plasticity
Oxytocin immunology
Oxytocin metabolism
Phylogeny
Prosencephalon immunology
RNA, Messenger metabolism
Rabbits
Rats
Receptors, Oxytocin genetics
Receptors, Oxytocin immunology
Receptors, Vasopressin genetics
Receptors, Vasopressin immunology
Social Behavior
Vasotocin immunology
Cichlids metabolism
Oxytocin analogs & derivatives
Prosencephalon metabolism
Receptors, Oxytocin metabolism
Receptors, Vasopressin metabolism
Vasotocin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6300
- Volume :
- 44
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of chemical neuroanatomy
- Publication Type :
- Academic Journal
- Accession number :
- 22668656
- Full Text :
- https://doi.org/10.1016/j.jchemneu.2012.05.002