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Effect of short-term interferon-β treatment on cytokines in multiple sclerosis: significant modulation of IL-17 and IL-23.
- Source :
-
Cytokine [Cytokine] 2012 Aug; Vol. 59 (2), pp. 400-2. Date of Electronic Publication: 2012 May 30. - Publication Year :
- 2012
-
Abstract
- Therapeutic effect of interferon-β (IFN-β) treatment has been associated with modulation of the balance between Th1, Th17, Th2 and regulatory T (Treg) cells, whereas the impact of disease modifying drugs on Th9-immunity in multiple sclerosis (MS) has not been studied. To investigate the short-term effects of IFN-β treatment on cytokines in MS, we determined serum levels of IL-17, IL-23, IL-10, IL-4, IFN-γ, IL-9 and TGF-β in relapsing remitting MS patients before and 2 months after IFN-β treatment by ELISA. MS patients showed increased IL-17, IL-23 and IL-4 levels and decreased IL-9 levels as compared to healthy controls. IFN-β treatment only reduced IL-17 and IL-23 levels, whereas the levels of other cytokines remained unchanged. IFN-β treatment appears to exert its earliest therapeutic effect on Th17-immunity. The influence of IL-9 on MS pathogenesis needs to be further studied.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Case-Control Studies
Female
Humans
Immunity drug effects
Male
Th17 Cells drug effects
Th17 Cells immunology
Time Factors
Interferon-beta pharmacology
Interferon-beta therapeutic use
Interleukin-17 immunology
Interleukin-23 immunology
Multiple Sclerosis drug therapy
Multiple Sclerosis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0023
- Volume :
- 59
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cytokine
- Publication Type :
- Academic Journal
- Accession number :
- 22652415
- Full Text :
- https://doi.org/10.1016/j.cyto.2012.05.004