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Stem cell markers aldehyde dehydrogenase type 1 and nestin expressions in renal cell cancer.
- Source :
-
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica [Arch Ital Urol Androl] 2012 Mar; Vol. 84 (1), pp. 7-11. - Publication Year :
- 2012
-
Abstract
- Objectives: To identify stem cell markers aldehyde dehydrogenase type 1 (ALDH-1) and nestin expression in renal cell carcinoma (RCC).<br />Materials and Methods: 95 RCC patients who had radical or partial nephrectomy were included in this study. Normal renal tissue samples of the same patients were designated as the control group. Paraffin blocks of RCC patients were studied immunohistochemically. Expressions were analyzed semiquantitively. Relation of tumor grade and stage with these expressions was determined. Results were calculated with Mann Whitney U and Kruskal Wallis tests.<br />Results: There were 55 male (57.8%) and 40 (42.2%) female patients in the study. Age and sex of the patients were not correlated with their antibody expressions (p > 0.05). ALDH-1 and nestin expression was higher in cancer tissues than normal tissues (p < 0.05). Nestin expression in renal cencer tissue was inversely related with tumor stage (p < 0.05) but there was no relation with Fuhrman grade. ALDH-1 expression was correlated with tumor grade (p < 0.05) but not with tumor stage (p > 0.05).<br />Conclusions: ALDH-land nestin expression have a role in RCC pathophysiology. There is a need to perform more studies about stem cell markers in RCC with more patients and in these future studies lymph node metastasis, distant organ metastasis and survival rates should be included.
- Subjects :
- Adult
Aged
Aged, 80 and over
Aldehyde Dehydrogenase 1 Family
Biomarkers, Tumor genetics
Carcinoma, Renal Cell enzymology
Carcinoma, Renal Cell genetics
Carcinoma, Renal Cell surgery
Female
Humans
Intermediate Filament Proteins genetics
Isoenzymes genetics
Kidney Neoplasms enzymology
Kidney Neoplasms genetics
Kidney Neoplasms surgery
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
Nephrectomy methods
Nerve Tissue Proteins genetics
Nestin
Predictive Value of Tests
Prognosis
Retinal Dehydrogenase genetics
Retrospective Studies
Sensitivity and Specificity
Biomarkers, Tumor metabolism
Carcinoma, Renal Cell metabolism
Carcinoma, Renal Cell pathology
Intermediate Filament Proteins metabolism
Isoenzymes metabolism
Kidney Neoplasms metabolism
Kidney Neoplasms pathology
Nerve Tissue Proteins metabolism
Retinal Dehydrogenase metabolism
Stem Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1124-3562
- Volume :
- 84
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
- Publication Type :
- Academic Journal
- Accession number :
- 22649953