Back to Search
Start Over
Neoadjuvant chemotherapy (NACT) is an effective way of managing elderly women with advanced stage ovarian cancer (FIGO Stage IIIC and IV).
- Source :
-
Journal of surgical oncology [J Surg Oncol] 2013 Feb; Vol. 107 (2), pp. 195-200. Date of Electronic Publication: 2012 May 30. - Publication Year :
- 2013
-
Abstract
- Background: To compare outcomes in women ≥ age 70 who receive neoadjuvant chemotherapy (NACT) for advanced epithelial ovarian cancer (EOC) followed by cytoreductive surgery with those undergoing upfront cytoreductive surgery followed by the same chemotherapy.<br />Methods: A retrospective cohort study was performed for women ≥ age 70 with Stage IIIC or Stage IV EOC from 1996 to 2009.<br />Results: Sixty-two patients who underwent upfront cytoreductive surgery and 42 patients who received NACT were eligible for analysis. Patients receiving NACT were significantly more likely to have Stage IV disease (P = 0.004). Cytoreduction to no macroscopic disease was achieved in 71.4% of women who received NACT and 28.1% of women undergoing upfront surgery (P < 0.001). NACT patients had significantly less blood loss at surgery (P = 0.01), required fewer small bowel resections (P = 0.009), had shorter ICU stays (P = 0.02) and fewer hospital days (P = 0.04). NACT patients experienced a trend toward an improved progression-free survival (P = 0.078); however, no statistically significant differences were found in either the progression-free or overall survival analyses.<br />Conclusion: NACT is associated with reduced perioperative morbidity in elderly patients with advanced stage ovarian cancer.<br /> (Copyright © 2012 Wiley Periodicals, Inc.)
- Subjects :
- Age Factors
Aged
Aged, 80 and over
Antineoplastic Agents administration & dosage
Carboplatin administration & dosage
Carcinoma, Ovarian Epithelial
Chemotherapy, Adjuvant
Cohort Studies
Drug Administration Schedule
Female
Humans
Neoadjuvant Therapy
Neoplasm Staging
Neoplasms, Glandular and Epithelial mortality
Neoplasms, Glandular and Epithelial pathology
Neoplasms, Glandular and Epithelial surgery
Ovarian Neoplasms mortality
Ovarian Neoplasms pathology
Ovarian Neoplasms surgery
Paclitaxel administration & dosage
Retrospective Studies
Survival Analysis
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Neoplasms, Glandular and Epithelial drug therapy
Ovarian Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1096-9098
- Volume :
- 107
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 22648987
- Full Text :
- https://doi.org/10.1002/jso.23171