Synthesis and characterization of PEG-based drug-responsive biohybrid hydrogels.

Authors :: Gübeli RJ
Ehrbar M
Fussenegger M
Friedrich C
Weber W
Source :: Macromolecular rapid communications [Macromol Rapid Commun] 2012 Aug 14; Vol. 33 (15), pp. 1280-5. Date of Electronic Publication: 2012 May 31.
Publication Year :: 2012
Abstract: Interactive materials being responsive to a biocompatible stimulus represent a promising approach for future therapeutic applications. In this study, we present a novel biohybrid material synthesized from biocompatible components being stimulus-responsive to the pharmaceutically approved small-molecule novobiocin. The hydrogel design is based on the gyrase B (GyrB) protein, which is covalently grafted to multi-arm polyethylene glycol (PEG) using a Michael-type addition reaction. Upon addition of the GyrB-dimerizing substance coumermycin, stable hydrogels form which can be dissolved in a dose-adjustable manner by the antibiotic novobiocin. The switchable properties of this PEG-based hydrogel are favorable for future applications in tissue engineering and as externally controlled drug depot.<br /> (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Biocompatible Materials chemical synthesis
DNA Gyrase chemistry
DNA Gyrase metabolism
Hydrogels chemistry
Topoisomerase II Inhibitors
Aminocoumarins chemistry
Biocompatible Materials chemistry
Hydrogels chemical synthesis
Novobiocin chemistry
Polyethylene Glycols chemistry

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